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KMID : 0644120150280010046
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Journal of Oriental Gynecology
2015 Volume.28 No. 1 p.46 ~ p.57
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Effects of Trogopterorum Faeces on the Apoptostic Cell Death in Breast Cancer Cells
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Song Yu-Rim
Kim Ji-Eun
Yang Seung-Jeong
Park Kyung-Mi
Jung Su-Jung
Cho Seong-Hee
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Abstract
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Objectives: This study was designed to investigate the effects of Trogopterorum Faeces on the apoptostic cell death in breast cancer cells.
Methods: In the experiment, the effects of Trogopterorum Faeces on proliferation rates and type of cell death were investigated using MCF-7 cells in vitro. The effects on expression levels of caspase 3 and caspase 9 were also investigated.
Results: The effects on expression levels of caspase 3 and caspase 9 were also investigated. In the present results, treatment with Trogopterorum Faeces decreased proliferation rates in a dose dependent manner. ID50 (50 % inhibitory dosage) was 177.2 μg/ml. In addition, treatment with Trogopterorum Faeces increased percentage of apoptotic cells. Finally the expression level of caspase 3 and caspase 9 were elevated by treatment with Trogopterorum Faeces respectively.
Conclusions: This study suggests that Trogopterorum Faeces can trigger caspase dependent apoptosis in MCF-7 cells.
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KEYWORD
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Trogopterorum Faeces, Apoptostic Cell Death, Breast Cancer Cells
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